EmailPrint this page Bookmark this page

Treatment options for glaucoma: eyedrops without preservatives

If you’ve been prescribed timolol, a classic prescription eyedrop that doctors have trusted for many years, you have an option for taking it in a preservative-free form.

Preservatives can cause symptoms like burning, stinging, irritation, and redness

Preservatives in eyedrops used over time have also been shown to cause dry eye in some glaucoma patients.1

Glaucoma Treatment Without Preservatives

TIMOPTIC in OCUDOSE contains a classic FDA-approved glaucoma medication, timolol, that has been available for many years with preservatives in a multidose bottle. The difference is, patients taking preserved timolol may experience more signs and symptoms of irritation than those who take a preservative-free form.2

In fact, a large clinical study has shown that patients who had been using an eyedrop with preservatives who were switched to a preservative-free form, had a significant reduction in preservative-related symptoms.2

Please see full Prescribing Information by clicking on the link above.


Preservative-free TIMOPTIC® in OCUDOSE® is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Preservative-free TIMOPTIC® in OCUDOSE® may be used when a patient is sensitive to the preservative in Timoptic (timolol maleate ophthalmic solution), benzalkonium chloride, or when use of a preservative-free topical medication is advisable.


Timoptic is contraindicated in patients with: bronchial asthma; a history of bronchial asthma; severe chronic obstructive pulmonary disease; sinus bradycardia; second or third degree atrioventricular block; overt cardiac failure; cardiogenic shock; hypersensitivity to any component of this product.

This drug is absorbed systemically. The same adverse reactions found with systemic administration of beta-adrenergic blocking agents may occur with topical administration. Severe respiratory or cardiac reactions, including death, have been reported following systemic or ophthalmic administration of timolol maleate. Timoptic should be used with caution in patients with cerebrovascular insufficiency.

The most frequently reported adverse experiences have been burning and stinging upon instillation.

You are encouraged to report side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

References: 1. Baudouin, Detrimental effect of preservatives in eyedrops:implications for the treatment of glaucoma, Acta Ophthalmol. 2008:86:716–726. 2. Jaenen N, Baudouin C, Pouliquen P, Manni G, Figueiredo A, Zeyen T. Ocular symptoms and signs with preserved and preservative-free glaucoma medications. Eur J Ophthalmol. 2007;17(3):341-349.


Prescribing Information important safety information instant coupon: up to $60 in savings Ocudose Form
©2012 Valeant Ophthalmics, a division of Valeant Pharmaceuticals
North America LLC Bridgewater, NJ 08807